After thinking about the many metabolites of methyl' and dexa', we asked ourselves how likely was it that they might elute in regions that could cause problems.
We poked at this two ways, a Monte Carlo simulation, and analytically. We assumed 19 metabolites that are free to co-elute with each other, in the 882 seconds between 800 and 1682 seconds, with a uniform distribution. This encompasses the IS to the bumps past the ostensible Pdiols.
The Monte Carlo method made a sheet of 19 columns and 1000 rows, and placed a random value in the range in each cell. The result was around a 0.5 probability of one co-eluting between the start of the 5bA and the end of the 5aA, being the 34 seconds between 1326 and 1360.
The analytic approach yielded:
Probability of peak NOT occurring in range of interest is
Probability of all 19 peaks NOT occurring in range of interest
So the probability of one or more occuring in range of interest is
1-((882-34)/882)^19 = 0.526
In English, there seems to be a 52% chance there is co-elution of at least one of the metabolites of the TUE'd medication showing up in a region likely to conflict with the measured peaks.
These are first guesses, but more or less agree. We appreciate correction and feedback.